Touch-screen visual reversal learning is mediated by value encoding and signal propagation in the orbitofrontal cortex.

ABSTRACT: Behavioral inflexibility is a common symptom of neuropsychiatric disorders which can have a major detrimental impact on quality of life. While the orbitofrontal cortex (OFC) has been strongly implicated in behavioral flexibility in rodents across paradigms, our understanding of how the OFC mediates these behaviors is rapidly adapting. Here we examined neuronal activity during reversal learning by coupling in vivo electrophysiological recording with a mouse touch-screen learning paradigm to further elucidate the role of the OFC in updating reward value. Single unit and oscillatory activity was recorded during well-learned discrimination and 3 distinct phases of reversal (early, chance and well-learned). During touch-screen performance, OFC neuronal firing tracked rewarded responses followin

SUBMITTER: Marquardt K 

PROVIDER: S-EPMC5372695 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature