Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases.

ABSTRACT: Improved understanding of the interplay between host and microbes stands to illuminate new avenues for disease diagnosis, treatment, and prevention. Here, we provide a high-resolution view of the dynamics between host and gut microbiota during antibiotic-induced intestinal microbiota depletion, opportunistic Salmonella typhimurium and Clostridium difficile pathogenesis, and recovery from these perturbed states in a mouse model. Host-centric proteome and microbial community profiles provide a nuanced longitudinal view, revealing the interdependence between host and microbiota in evolving dysbioses. Time- and condition-specific molecular and microbial signatures are evident and clearly distinguished from pathogen-independent inflammatory fingerprints. Our data reveal that mice recovering fro

SUBMITTER: Lichtman JS 

PROVIDER: S-EPMC5372703 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature