Common Chemical Inductors of Replication Stress:  Focus on Cell-Based Studies.

ABSTRACT: DNA replication is a highly demanding process regarding the energy and material supply and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or stalling of DNA synthesis and/or replication forks is referred to as replication stress (RS). Owing to the complexity and requirements of replication, a plethora of factors may interfere and challenge the genome stability, cell survival or affect the whole organism. This review outlines chemical compounds that are known inducers of RS and commonly used in laboratory research. These compounds act on replication by direct interaction with DNA causing DNA crosslinks and bulky lesions (cisplatin), chemical interference with the metabolism of deoxyribonucleotide triphosphates (hydroxyurea), direct inhibition of the act

SUBMITTER: Vesela E 

PROVIDER: S-EPMC5372731 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature