Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function.

ABSTRACT: RNAs are central to all gene expression through the control of protein synthesis. Four major nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide sequence variation, but are limited in contributions to structural variation as well as distinct chemical properties. The ability of RNAs to play multiple roles in cellular metabolism is made possible by extensive variation in length, conformational dynamics, and the over 100 post-transcriptional modifications. There are several reviews of the biochemical pathways leading to RNA modification, but the physicochemical nature of modified nucleosides and how they facilitate RNA function is of keen interest, particularly with regard to the contributions of modified nucleosides. Transfer RNAs (tRNAs) are the most extensivel

SUBMITTER: Vare VY 

PROVIDER: S-EPMC5372741 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature