Myocardial aging as a T-cell-mediated phenomenon.

ABSTRACT: In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial structure and function in elderly mice. Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an accumulation of activated CD4⁺ Foxp3^- (forkhead box P3) IFN-γ⁺ T cells in the heart-draining lymph nodes. A comprehensive characterization of different aged

SUBMITTER: Ramos GC 

PROVIDER: S-EPMC5373357 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature