Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.

ABSTRACT: Acid-sensing ion channels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological range. Recent reports have revealed that postsynaptically localized ASICs contribute to the excitatory postsynaptic current by responding to the transient acidification of the synaptic cleft that accompanies neurotransmission. In response to such brief acidic transients, both recombinant and native ASICs show extremely rapid deactivation in outside-out patches when jumping from a pH 5 stimulus to a single resting pH of 8. Given that the resting pH of the synaptic cleft is highly dynamic and depends on recent synaptic activity, we explored the kinetics of ASIC1a and 1a/2a heteromers to such brief pH transients over a wider [H⁺] range to approximate neuronal condi

SUBMITTER: MacLean DM 

PROVIDER: S-EPMC5373395 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature