A multi-scale computational model of the effects of TMS on motor cortex.

ABSTRACT: The detailed biophysical mechanisms through which transcranial magnetic stimulation (TMS) activates cortical circuits are still not fully understood. Here we present a multi-scale computational model to describe and explain the activation of different pyramidal cell types in motor cortex due to TMS. Our model determines precise electric fields based on an individual head model derived from magnetic resonance imaging and calculates how these electric fields activate morphologically detailed models of different neuron types. We predict neural activation patterns for different coil orientations consistent with experimental findings. Beyond this, our model allows us to calculate activation thresholds for individual neurons and precise initiation sites of individual action potentials on the neu

SUBMITTER: Seo H 

PROVIDER: S-EPMC5373428 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature