Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection.

ABSTRACT: Malaria is caused by parasites of the genus Plasmodium. All human-infecting Plasmodium species can establish long-lasting chronic infections^1-5, creating an infectious reservoir to sustain transmission^1,6. It is widely accepted that the maintenance of chronic infection involves evasion of adaptive immunity by antigenic variation⁷. However, genes involved in this process have been identified in only two of five human-infecting species: Plasmodium falciparum and Plasmodium knowlesi. Furthermore, little is understood about the early events in the establishment of chronic infection in these species. Using a rodent model we demonstrate that from the infecting population, only a minority of parasites, expressing one of several clusters of virulence-associated pir

SUBMITTER: Brugat T 

PROVIDER: S-EPMC5373435 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature