Arterial and Cellular Inflammation in Patients with CKD.

ABSTRACT: CKD associates with a 1.5- to 3.5-fold increased risk for cardiovascular disease. Both diseases are characterized by increased inflammation, and in patients with CKD, elevated C-reactive protein level predicts cardiovascular risk. In addition to systemic inflammation, local arterial inflammation, driven by monocyte-derived macrophages, predicts future cardiovascular events in the general population. We hypothesized that subjects with CKD have increased arterial and cellular inflammation, reflected by ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography computed tomography (PET/CT) of the arterial wall and a migratory phenotype of monocytes. We assessed ¹⁸F-FDG uptake in the arterial wall in 14 patients with CKD (mean±SD age: 59±5 years, mean±SD eGF

SUBMITTER: Bernelot Moens SJ 

PROVIDER: S-EPMC5373444 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature