Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults.

ABSTRACT: Within monocytes, 1,25-dihydroxyvitamin D [1,25(OH)₂D] is important for production of cathelicidins, which in turn, are critical for antibacterial action. Fibroblast growth factor 23 (FGF23) decreases 1,25(OH)₂D production and thus, could increase infection risk. We examined this possibility in 3141 community-dwelling adults ages ≥65 years old at baseline in the Cardiovascular Health Study using Cox proportional hazards models to examine the association between FGF23 concentrations and first infection-related hospitalizations and determine whether associations differed by the presence of CKD (eGFR<60 ml/min per 1.73 m² [n=832] or urine albumin-to-creatinine ratio >30 mg/g [n=577]). Mean±SD age of participants was 78±5 years old, 60% of partici

SUBMITTER: Nowak KL 

PROVIDER: S-EPMC5373449 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature