Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics.

ABSTRACT: A number of proteomic and peptidomic analyses of urine from diabetic subjects have been published in the quest for a biomarker that predicts progression of nephropathy. Less attention has been paid to the relationships between urinary proteins and the underlying biological processes revealed by the analyses. In this review, we focus on the biological processes identified by studying urinary proteins and protein-protein interactions at each stage of diabetic nephropathy to provide an overview of the events underlying progression of kidney disease reflected in the urine. In uncomplicated diabetes, proteomic/peptidomic analyses indicate that early activation of fibrotic pathways in the kidney occurs before the onset of microalbuminuria. In incipient nephropathy, when albumin excretion rates a

SUBMITTER: Van JA 

PROVIDER: S-EPMC5373465 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature