Predicting first trimester pregnancy outcome: derivation of a multiple marker test.

ABSTRACT:

Objective

To predict first trimester pregnancy outcome using biomarkers in a multicenter cohort.

Design

Case-control study.

Setting

Three academic centers.

Patient(s)

Women with pain and bleeding in early pregnancy.

Intervention(s)

Sera from women who were 5-12 weeks' gestational age with ectopic pregnancy (EP), viable intrauterine pregnancy (IUP), and miscarriage/spontaneous abortion (SAB) was analyzed by ELISA and immunoassay for activin A, inhibin A, P, A Disintegrin And Metalloprotease-12, pregnancy-associated plasma protein A (PAPP-A), pregnancy specific B₁-glycoprotein (SP₁), placental-like growth factor, vascular endothelial growth factor, glycodelin (Glyc), and hCG. Classification trees were developed to optimize sensitivity

SUBMITTER: Senapati S 

PROVIDER: S-EPMC5373488 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature