Steeper change in body mass across four decades predicts poorer cardiometabolic outcomes at midlife.

ABSTRACT:

Objective

This study examined patterns of change in adiposity across four decades starting in young adulthood as well as associations between change and midlife cardiometabolic outcomes.

Methods

BMI was assessed at ages 20, 40, 56, and 62 years in 977 male veterans from the Vietnam Era Twin Study of Aging. Age 62 (range 56-66) cardiometabolic outcomes included hypertension, diabetes, dyslipidemia, inflammation, and ischemic heart disease. Analyses included latent growth modeling (LGM), latent class growth modeling (LCGM), and logistic regression models.

Results

Linear BMI slope was associated with all outcomes. Accelerated (quadratic) BMI slope was significantly associated with greater risk for hypertension, diabetes, dyslipidemia, and inflammation; odds ratios ranged

SUBMITTER: Xian H 

PROVIDER: S-EPMC5373489 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature