Exercise training-induced improvement in skeletal muscle PGC-1α-mediated fat metabolism is independent of dietary glycemic index.

ABSTRACT:

Objective

This study hypothesized that a low-glycemic diet combined with exercise would increase expression of nuclear regulators of fat transport and oxidation in insulin-resistant skeletal muscle.

Method

Nineteen subjects (64 ± 1 y; 34 ± 1 kg/m² ) were randomized to receive isocaloric high-glycemic-index (HiGIX; 80 ± 0.6 units, n = 10) or low-glycemic-index (LoGIX; 40 ± 0.3 units, n = 9) diets combined with supervised exercise (1 h/d, 5 d/wk at ∼85% HR_max ) for 12 weeks. Insulin sensitivity was determined by hyperinsulinemic-euglycemic clamp. Skeletal muscle biopsies were obtained before and after the intervention to assess fasting gene and protein expression.

Results

Weight loss was similar for both groups (9.5 ± 1.3 kg). Likewise, improvement

SUBMITTER: Mulya A 

PROVIDER: S-EPMC5373498 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature