Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq.

ABSTRACT:

Background

Filarial nematodes currently infect up to 54 million people worldwide, with millions more at risk for infection, representing the leading cause of disability in the developing world. Brugia malayi is one of the causative agents of lymphatic filariasis and remains the only human filarial parasite that can be maintained in small laboratory animals. Many filarial nematode species, including B. malayi, carry an obligate endosymbiont, the alpha-proteobacteria Wolbachia, which can be eliminated through antibiotic treatment. Elimination of the endosymbiont interferes with development, reproduction, and survival of the worms within the mamalian host, a clear indicator that the Wolbachia are crucial for survival of the parasite. Little is understood about the mechanism underlying

SUBMITTER: Grote A 

PROVIDER: S-EPMC5373514 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature