Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

ABSTRACT: The cardiac conduction system (CCS) is composed of specialized cardiomyocytes that initiate and maintain cardiac rhythm. Any perturbation to the normal sequence of electrical events within the heart can result in cardiac arrhythmias. To understand how cardiac rhythm is established at the molecular level, several genetically modified mouse lines expressing Cre recombinase within specific CCS compartments have been created. In general, Cre driver lines have been generated either by homologous recombination of Cre into an endogenous locus or Cre expression driven by a randomly inserted transgene. However, haploinsufficiency of the endogenous gene compromises the former approach, while position effects negatively impact the latter. To address these limitations, we generated a Cre driver line f

SUBMITTER: Bhattacharyya S 

PROVIDER: S-EPMC5373586 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature