Methodological concerns with laser speckle contrast imaging in clinical evaluation of microcirculation.

ABSTRACT:

Background

Laser Speckle Contrast Imaging (LSCI) is a non-invasive and fast technique for measuring microvascular blood flow that recently has found clinical use for burn assessment and evaluation of flaps. Tissue motion caused by for example breathing or patient movements may however affect the measurements in these clinical applications, as may distance between the camera and the skin and tissue curvature. Therefore, the aims of this study were to investigate the effect of frame rate, number of frames/image, movement of the tissue, measuring distance and tissue curvature on the measured perfusion.

Methods

Methyl nicotinate-induced vasodilation in the forearm skin was measured using LSCI during controlled motion at different speeds, using different combinations of frame rat

SUBMITTER: Zotterman J 

PROVIDER: S-EPMC5373607 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature