Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

ABSTRACT: Kidney podocytes' function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined how imbalances in regulation of actin cytoskeletal dynamics could result in pathological morphology. We obtained 3-D electron microscopy images of podocytes and used quantitative features to build dynamical models to investigate how regulation of actin dynamics within foot processes controls local morphology. We find that imbalances in regulation of actin bundling lead to chaotic spatial patterns that could impair the foot process morphology. Simulation results are consistent with experimental

SUBMITTER: Falkenberg CV 

PROVIDER: S-EPMC5373631 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature