Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis.

ABSTRACT:

Objective

To identify cell-surface antibodies in patients with neuromyotonia and to describe the main clinical implications.

Methods

Sera of 3 patients with thymoma-associated neuromyotonia and myasthenia gravis were used to immunoprecipitate and characterize neuronal cell-surface antigens using reported techniques. The clinical significance of antibodies against precipitated proteins was assessed with sera of 98 patients (neuromyotonia 46, myasthenia gravis 52, thymoma 42; 33 of them with overlapping syndromes) and 219 controls (other neurologic diseases, cancer, and healthy volunteers).

Results

Immunoprecipitation studies identified 3 targets, including the Netrin-1 receptors DCC (deleted in colorectal carcinoma) and UNC5A (uncoordinated-5A) as well as Caspr2 (conta

SUBMITTER: Torres-Vega E 

PROVIDER: S-EPMC5373776 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature