Corpus callosal atrophy and associations with cognitive impairment in Parkinson disease.

ABSTRACT:

Objective

To investigate atrophy of the corpus callosum on MRI in Parkinson disease (PD) and its relationship to cognitive impairment.

Methods

One hundred patients with PD and 24 healthy control participants underwent clinical and neuropsychological evaluations and structural MRI brain scans. Participants with PD were classified as cognitively normal (PD-NC; n = 28), having mild cognitive impairment (PD-MCI; n = 47), or having dementia (PDD; n = 25) by Movement Disorder Society criteria. Cognitive domain (attention/working memory, executive function, memory, language, visuospatial function) z scores were calculated. With the use of FreeSurfer image processing, volumes for total corpus callosum and its subsections (anterior, midanterior, central, midposterior, posterio

SUBMITTER: Goldman JG 

PROVIDER: S-EPMC5373777 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature