Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.

ABSTRACT:

Objective

To evaluate the association between sleep duration and the risk of incident dementia and brain aging.

Methods

Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6-9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance.

Results

We observed 234 cases of all-cause dementia over 10 years of follow-up. In multivariable analyses, prolonged sleep duration was associated with an increased risk of incident dementia (hazard ratio [HR] 2.01; 95% confidence interval [CI] 1.24-3.26). These findings were driven by persons wi

SUBMITTER: Westwood AJ 

PROVIDER: S-EPMC5373785 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature