Urinary p75^ECD: A prognostic, disease progression, and pharmacodynamic biomarker in ALS.

ABSTRACT:

Objective

To evaluate urinary neurotrophin receptor p75 extracellular domain (p75^ECD) levels as disease progression and prognostic biomarkers in amyotrophic lateral sclerosis (ALS).

Methods

The population in this study comprised 45 healthy controls and 54 people with ALS, 31 of whom were sampled longitudinally. Urinary p75^ECD was measured using an enzyme-linked immunoassay and validation included intra-assay and inter-assay coefficients of variation, effect of circadian rhythm, and stability over time at room temperature, 4°C, and repeated freeze-thaw cycles. Longitudinal changes in urinary p75^ECD were examined by mixed model analysis, and the prognostic value of baseline p75^ECD was explored by survival analysis.

Results

Con

SUBMITTER: Shepheard SR 

PROVIDER: S-EPMC5373786 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature