Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers.

ABSTRACT:

Background

Similarities between behavioral and substance addictions exist. However, direct neurobiological comparison between addictive disorders is rare. Determination of disorder-specificity (or lack thereof) of alterations within white-matter microstructures will advance understanding of the pathophysiology of addictions.

Methods

We compared white-matter microstructural features between individuals with gambling disorder (GD; n=38), cocaine-use disorder (CUD; n=38) and healthy comparison (HC; n=38) participants, as assessed using diffusion-weighted magnetic resonance imaging (dMRI). To provide a more precise estimate of diffusion within regions of complex architecture (e.g., cortico-limbic tracts), analyses were conducted using a crossing-fiber model incorporating local-o

SUBMITTER: Yip SW 

PROVIDER: S-EPMC5373810 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature