Ontology highlight
ABSTRACT:
SUBMITTER: Gui Y
PROVIDER: S-EPMC5373841 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Nature genetics 20110807 9
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) i ...[more]