Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.

ABSTRACT:

Background

The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms.

Methods

We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asymptomatic patients to identify a protein signature for high-risk atherosclerotic plaques. Proteomics data were integrated with gene expression profiling of 121 carotid endarterectomies and an analysis of protein secretion by lipid-loaded human vascular smooth muscle cells. Finally, epidemiolog

SUBMITTER: Langley SR 

PROVIDER: S-EPMC5373893 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature