Association between renal function and chemotherapy-related toxicity in older adults with cancer.

ABSTRACT:

Purpose

To evaluate the association between renal function (RF) and chemotherapy-related toxicity (CRT) in older adults with cancer and to compare the effect of different RF formulas and body weight measurements on this association.

Methods

This is a secondary analysis of data from a prospective multicenter study of patients ≥ age 65 who were starting a new chemotherapy regimen. RF was estimated with 4 formulas (modified Jelliffe [Jelliffe], Cockcroft-Gault [CG], Wright, and Modification of Diet in Renal Disease [MDRD]), using actual, ideal and adjusted body weights for 492 patients. The association between baseline RF and grade 3-5 CRT was evaluated by unconditional logistic regression.

Results

As a continuous variable, decreased creatinine clearance (CrCl) calculate

SUBMITTER: Peterson LL 

PROVIDER: S-EPMC5373948 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature