Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys.

ABSTRACT:

Objective

Obesity exists with and without accompanying cardiometabolic disease, termed metabolically unhealthy obesity (MUO) and healthy obesity (MHO), respectively. Underlying differences in the ability of subcutaneous (SQ) fat to respond to nutrient excess are emerging as a key pathway. This study aimed to document the first spontaneous animal model of MHO and MUO and differences in SQ adipose tissue.

Methods

Vervet monkeys (Chlorocebus aethiops; N = 171) were screened for metabolic syndrome. A subset of MHO and MUO monkeys (n = 6/group) had SQ fat biopsies collected for histological evaluations and examination of key mitochondrial proteins.

Results

Obesity was seen in 20% of monkeys, and within this population, 31% were healthy, which mirrors human prevalence estim

SUBMITTER: Kavanagh K 

PROVIDER: S-EPMC5373959 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature