Genomic variants at 20p11 associated with body fat mass in the European population.

ABSTRACT:

Objective

Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.

Methods

Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207), and the Omaha osteoporosis study (N = 968).

Results

At the genome-wide significance level (α = 5.0×10^-8 ), a cluster of 10 single-nucleotide polymorphisms (SNPs) at chromosomal region 20p11 that were associated with BFM (lead SNP rs2069126, P = 1.82×10^-9 , closest gene

SUBMITTER: Pei YF 

PROVIDER: S-EPMC5373963 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature