Biomarkers associated with bronchopulmonary dysplasia/mortality in premature infants.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) portends lifelong organ impairment and death. Our ability to predict BPD in first days of life is limited, but could be enhanced using novel biomarkers.

Methods

Using an available clinical and urine biomarker database obtained from a prospective 113 infant cohort (birth weight ≤1,200 g and/or gestational age ≤31 wk), we evaluated the independent association of 14 urine biomarkers with BPD/mortality.

Results

Two of the 14 urine biomarkers were independently associated with BPD/mortality after controlling for gestational age (GA), small for gestational age (SGA), and intubation status. The best performing protein was clusterin, a ubiquitously expressed protein and potential sensor of oxidative stress associated with lung funct

SUBMITTER: Balena-Borneman J 

PROVIDER: S-EPMC5373977 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature