HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity.

ABSTRACT:

Objective

To test the hypothesis that HIV infection impairs the beneficial effects of weight loss on insulin sensitivity, adipose tissue inflammation, and endoplasmic reticulum (ER) stress.

Methods

A prospective clinical trial evaluated the effects of moderate diet-induced weight loss on body composition, metabolic function, and adipose tissue biology in women with obesity who were HIV-seronegative (HIV-) or HIV-positive (HIV+). Body composition, multiorgan insulin sensitivity (assessed by using a two-stage hyperinsulinemic-euglycemic clamp procedure with stable isotopically labeled tracer infusions), and adipose tissue expression of markers of inflammation, autophagy, and ER stress were evaluated in 8 HIV- and 20 HIV+ women with obesity before and after diet-induced weight

SUBMITTER: Reeds DN 

PROVIDER: S-EPMC5373981 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature