The placental interleukin-6 signaling controls fetal brain development and behavior.

ABSTRACT: Epidemiological studies show that maternal immune activation (MIA) during pregnancy is a risk factor for autism. However, mechanisms for how MIA affects brain development and behaviors in offspring remain poorly described. To determine whether placental interleukin-6 (IL-6) signaling is required for mediating MIA on the offspring, we generated mice with restricted deletion of the receptor for IL-6 (IL-6Rα) in placental trophoblasts (Cyp19-Cre⁺;Il6ra^fl/fl), and tested offspring of Cyp19-Cre⁺;Il6ra^fl/fl mothers for immunological, pathological and behavioral abnormalities following induction of MIA. We reveal that MIA results in acute inflammatory responses in the fetal brain. Lack of IL-6 signaling in trophoblasts effectively blocks MIA-induced inf

SUBMITTER: Wu WL 

PROVIDER: S-EPMC5373986 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature