Nicotinic modulation of salience network connectivity and centrality in schizophrenia.

ABSTRACT: Although functional abnormalities of the salience network are associated with schizophrenia, the acute effects of nicotine on its function and network dynamics during the resting state in patients are poorly understood. In this study, the effects of a 7 mg nicotine patch (vs. placebo) on salience network connectivity were examined in 17 patients with schizophrenia and 19 healthy subjects. We hypothesized abnormal connectivity between the salience network and other major networks (e.g. executive network) in patients under placebo administration and amelioration of this difference after nicotine. We also examined effects of nicotine on betweenness centrality (a measure of the influence of a region on information transfer throughout the brain) and local efficiency (a measure of local informat

SUBMITTER: Smucny J 

PROVIDER: S-EPMC5373996 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature