Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.

ABSTRACT:

Purpose

We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians.

Methods

Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry.

Results

We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 × 10^-9 and P = 4.33 × 10^-8, respectively), and a novel 20:0-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 × 10^-10). We also confirmed the previously reported association of FADS1/2-rs102275 with 18:0 (P = 1.12 × 10^-5). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in

SUBMITTER: Zhu J 

PROVIDER: S-EPMC5374030 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature