An endovascular model of ischemic myopathy from peripheral arterial disease.

ABSTRACT:

Objective

Peripheral arterial disease (PAD) is a significant age-related medical condition with limited pharmacologic options. Severe PAD, termed critical limb ischemia, can lead to amputation. Skeletal muscle is the end organ most affected by PAD, leading to ischemic myopathy and debility of the patient. Currently, there are not any therapeutics to treat ischemic myopathy, and proposed biologic agents have not been optimized owing to a lack of preclinical models of PAD. Because a large animal model of ischemic myopathy may be useful in defining the optimal dosing and delivery regimens, the objective was to create and to characterize a swine model of ischemic myopathy that mimics patients with severe PAD.

Methods

Yorkshire swine (N = 8) underwent acute right hindlimb ischemi

SUBMITTER: Long CA 

PROVIDER: S-EPMC5374046 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature