Genetic determinants of serum vitamin B12 and their relation to body mass index.

ABSTRACT: Lower serum vitamin B12 levels have been related to adverse metabolic health profiles, including adiposity. We used a Mendelian randomization design to test whether this relation might be causal. We included two Danish population-based studies (n_total = 9311). Linear regression was used to test for associations between (1) serum vitamin B12 levels and body mass index (BMI), (2) genetic variants and serum vitamin B12 levels, and (3) genetic variants and BMI. The effect of a genetically determined decrease in serum vitamin B12 on BMI was estimated by instrumental variable regression. Decreased serum vitamin B12 associated with increased BMI (P < 1 × 10^-4). A genetic risk score based on eight vitamin B12 associated variants associated strongly with serum vitamin B12 (P <

SUBMITTER: Allin KH 

PROVIDER: S-EPMC5374184 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature