Effects of exogenous desmopressin on a model of heat stress nephropathy in mice.

ABSTRACT: Recurrent heat stress and dehydration have recently been shown experimentally to cause chronic kidney disease (CKD). One potential mediator may be vasopressin, acting via the type 2 vasopressin receptor (V₂ receptor). We tested the hypothesis that desmopressin accelerates CKD in mice subjected to heat stress and recurrent dehydration. Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle. Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin. The effects of the treatment on renal injury were assessed. Heat stress and recurrent dehydration induced functional changes (albuminuria, elevat

SUBMITTER: Roncal-Jimenez CA 

PROVIDER: S-EPMC5374310 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature