A novel mode of induction of the humoral innate immune response in Drosophila larvae.

ABSTRACT: Drosophila adults have been utilized as a genetically tractable model organism to decipher the molecular mechanisms of humoral innate immune responses. In an effort to promote the utility of Drosophila larvae as an additional model system, in this study, we describe a novel aspect of an induction mechanism for innate immunity in these larvae. By using a fine tungsten needle created for manipulating semi-conductor devices, larvae were subjected to septic injury. However, although Toll pathway mutants were susceptible to infection with Gram-positive bacteria as had been shown for Drosophila adults, microbe clearance was not affected in the mutants. In addition, Drosophila larvae were found to be sensitive to mechanical stimuli with respect to the activation of a s

SUBMITTER: Kenmoku H 

PROVIDER: S-EPMC5374318 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature