Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks.

ABSTRACT: Protein kinase CK2 is a small family of protein kinases that has been implicated in an expanding array of biological processes. While it is widely accepted that CK2 is a regulatory participant in a multitude of fundamental cellular processes, CK2 is often considered to be a constitutively active enzyme which raises questions about how it can be a regulatory participant in intricately controlled cellular processes. To resolve this apparent paradox, we have performed a systematic analysis of the published literature using text mining as well as mining of proteomic databases together with computational assembly of networks that involve CK2. These analyses reinforce the notion that CK2 is involved in a broad variety of biological processes and also reveal an extensive interplay between CK2 pho

SUBMITTER: Nunez de Villavicencio-Diaz T 

PROVIDER: S-EPMC5374431 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature