Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients.

ABSTRACT:

Objectives

To determine if time to initial antimicrobial is associated with progression of severe sepsis to septic shock.

Design

Retrospective cohort.

Setting

Six hundred fifty-six bed urban academic medical center.

Patients

Emergency department patients greater than or equal to 18 years old with severe sepsis and/or septic shock and antimicrobial administration within 24 hours. Patients with shock on presentation were excluded.

Interventions

Not available.

Measurements and main results

We identified 3,929 severe sepsis patients, with overall mortality 12.8%. Nine hundred eighty-four patients (25.0%) progressed to septic shock. The median time to antimicrobial was 3.77 hours (interquartile range = 1.96-6.42) in those who progressed versus 2.76 hou

SUBMITTER: Whiles BB 

PROVIDER: S-EPMC5374449 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature