Fine-mapping of genes determining extrafusal fiber properties in murine soleus muscle.

ABSTRACT: Muscle fiber cross-sectional area (CSA) and proportion of different fiber types are important determinants of muscle function and overall metabolism. Genetic variation plays a substantial role in phenotypic variation of these traits; however, the underlying genes remain poorly understood. This study aimed to map quantitative trait loci (QTL) affecting differences in soleus muscle fiber traits between the LG/J and SM/J mouse strains. Fiber number, CSA, and proportion of oxidative type I fibers were assessed in the soleus of 334 genotyped female and male mice of the F₃₄ generation of advanced intercross lines (AIL) derived from the LG/J and SM/J strains. To increase the QTL detection power, these data were combined with 94 soleus samples from the F₂ intercross of the sa

SUBMITTER: Carroll AM 

PROVIDER: S-EPMC5374456 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature