SNP by SNP by environment interaction network of alcoholism.

ABSTRACT:

Background

Alcoholism has a strong genetic component. Twin studies have demonstrated the heritability of a large proportion of phenotypic variance of alcoholism ranging from 50-80%. The search for genetic variants associated with this complex behavior has epitomized sequence-based studies for nearly a decade. The limited success of genome-wide association studies (GWAS), possibly precipitated by the polygenic nature of complex traits and behaviors, however, has demonstrated the need for novel, multivariate models capable of quantitatively capturing interactions between a host of genetic variants and their association with non-genetic factors. In this regard, capturing the network of SNP by SNP or SNP by environment interactions has recently gained much interest.

Results

Here

SUBMITTER: Zollanvari A 

PROVIDER: S-EPMC5374593 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature