High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility.

ABSTRACT:

Background

Previous studies from our group demonstrated the anti-inflammatory properties of statins on cardiopulmonary bypass (CPB), through inhibition of neutrophil transendothelial migration. We sought to determine the utility of preoperative statin on patients undergoing cardiac surgery, to investigate any moderating effects on the systemic inflammatory response (SIRS) with CPB, and to evaluate any clinical impact on our patients.

Methods

This is a prospective, randomised controlled trial with national regulatory body approval. Eligible patients were already on oral statin therapy. They were then randomly assigned to either investigation arm (n = 15, atorvastatin 80 mg for 2 weeks before surgery) or control arm (n = 15, no change to current statin therapy). Blood and urin

SUBMITTER: Chee YR 

PROVIDER: S-EPMC5374690 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature