Pathogenic Link Between Postextubation Pneumonia and Ventilator-Associated Pneumonia: An Experimental Study.

ABSTRACT:

Background

The presence of an endotracheal tube is the main cause for developing ventilator-associated pneumonia (VAP), but pneumonia can still develop in hospitalized patients after endotracheal tube removal (postextubation pneumonia [PEP]). We hypothesized that short-term intubation (24 hours) can play a role in the pathogenesis of PEP. To test such hypothesis, we initially evaluated the occurrence of lung colonization and VAP in sheep that were intubated and mechanically ventilated for 24 hours. Subsequently, we assessed the incidence of lung colonization and PEP at 48 hours after extubation in sheep previously ventilated for 24 hours.

Methods

To simulate intubated intensive care unit patients placed in semirecumbent position, 14 sheep were intubated and mechanically vent

SUBMITTER: Rezoagli E 

PROVIDER: S-EPMC5374725 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature