A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model.

ABSTRACT:

Purpose

To investigate the biocompatibility of an injectable hydrogel and its ability to control myopia progression in guinea pigs.

Methods

The study used a hydrogel synthesized from acrylated hyaluronic acid with a conjugated cell-binding peptide and enzymatically degradable crosslinker. Seven-day-old guinea pigs were first form deprived (FD) with diffusers for 1 week. One group was kept as an FD-only control; two groups received a sub-Tenon's capsule injection of either hydrogel or buffer (sham surgery) at the posterior pole of the eye. Form deprivation treatments were then continued for 3 additional weeks. Treatment effects were evaluated in terms of ocular axial length and refractive error. Safety was evaluated via intraocular pressure (IOP), visual acuity, flash electro

SUBMITTER: Garcia MB 

PROVIDER: S-EPMC5374882 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature