Default mode network differences between rigidity- and tremor-predominant Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) traditionally is characterized by tremor, rigidity, and bradykinesia, although cognitive impairment also is a common symptom. The clinical presentation of PD is heterogeneous and associated with different risk factors for developing cognitive impairment. PD patients with primary akinetic/rigidity (PDAR) are more likely to develop cognitive deficits compared to those with tremor-predominant symptoms (PDT). Because cognitive impairment in PD appears to be related to changes in the default mode network (DMN), this study tested the hypothesis that DMN integrity is different between PDAR and PDT subtypes.

Method

Resting state fMRI (rs-fMRI) and whole brain volumetric data were obtained from 17 PDAR, 15 PDT and 24 healthy controls (HCs) using a

SUBMITTER: Karunanayaka PR 

PROVIDER: S-EPMC5375103 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature