Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions.

ABSTRACT: The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only pathway with both nuclear and mitochondrial encoded proteins. The importance of the interactions between these two genomes has recently received more attention because of their potential evolutionary effects and how they may affect human health and disease. In many different organisms, healthy nuclear and mitochondrial genome hybrids between species or among distant populations within a species affect fitness and OxPhos functions. However, what is less understood is whether these interactions impact individuals within a single natural population. The significance of this impact depends on the strength of selection for mito-nuclear interactions. We examined whether mito-nuclear inte

SUBMITTER: Baris TZ 

PROVIDER: S-EPMC5375140 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature