Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression.

ABSTRACT: The viral genotype has been shown to play an important role in HIV pathogenesis following transmission. However, the viral phenotypic properties that contribute to disease progression remain unclear. Most studies have been limited to the evaluation of Gag function in the context of a recombinant virus backbone. Using this approach, important biological information may be lost, making the evaluation of viruses obtained during acute infection, representing the transmitted virus, a more biologically relevant model. Here, we evaluate the roles of viral infectivity and the replication capacity of viruses from acute infection in disease progression in women who seroconverted in the CAPRISA 004 tenofovir microbicide trial. We show that viral replication capacity, but not viral infectivity, correl

SUBMITTER: Selhorst P 

PROVIDER: S-EPMC5375681 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature