Altered fucosyltransferase expression in the superior temporal gyrus of elderly patients with schizophrenia.

ABSTRACT: Glycosylation is a post-translational modification that is an essential element in cell signaling and neurodevelopmental pathway regulation. Glycan attachment can influence the tertiary structure and molecular interactions of glycosylated substrates, adding an additional layer of regulatory complexity to functional mechanisms underlying central cell biological processes. One type of enzyme-mediated glycan attachment, fucosylation, can mediate glycoprotein and glycolipid cell surface expression, trafficking, secretion, and quality control to modulate a variety of inter- and intracellular signaling cascades. Building on prior reports of glycosylation abnormalities and evidence of dysregulated glycosylation enzyme expression in schizophrenia, we examined the protein expression of 5 key fucose

SUBMITTER: Mueller TM 

PROVIDER: S-EPMC5376218 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature