Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Rationale

Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart failure with preserved ejection fraction, but studies using pharmacological preparations of inorganic nitrate are lacking.

Objectives

To determine (1) the dose-response effect of potassium nitrate (KNO₃) on exercise capacity; (2) the population-specific pharmacokinetic and safety profile of KNO₃ in heart failure with preserved ejection fraction.

Methods and results

We randomized 12 subjects with heart failure with preserved ejection fraction to oral KNO₃ (n=9) or potassium chloride (n=3). Subjects received 6 mmol twice daily during week 1, followed by 6 mmol thrice daily during week 2. Supine cycle ergometry was performed at baseline (visit 1) an

SUBMITTER: Zamani P 

PROVIDER: S-EPMC5376233 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature