Novel phosphate-activated macrophages prevent ectopic calcification by increasing extracellular ATP and pyrophosphate.

ABSTRACT:

Purpose

Phosphorus is an essential nutrient involved in many pathobiological processes. Less than 1% of phosphorus is found in extracellular fluids as inorganic phosphate ion (Pi) in solution. High serum Pi level promotes ectopic calcification in many tissues, including blood vessels. Here, we studied the effect of elevated Pi concentration on macrophage polarization and calcification. Macrophages, present in virtually all tissues, play key roles in health and disease and display remarkable plasticity, being able to change their physiology in response to environmental cues.

Methods and results

High-throughput transcriptomic analysis and functional studies demonstrated that Pi induces unpolarized macrophages to adopt a phenotype closely resembling that of alternatively-activa

SUBMITTER: Villa-Bellosta R 

PROVIDER: S-EPMC5376322 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature